44th Symposium on Hormones and Cell Regulation

EUROPEAN SOCIETY OF ENDOCRINOLOGY (ESE)   
INOSITOL LIPIDS IN HEALTH AND DISEASES

Programme:

WEDNESDAY 16th October 2019   

■ 15.00-16.00: Bus arrival and cold lunch     
■ 16.00-16:10: Welcome words     

Session 1: Phosphoinositides in intracellular trafficking, organelle communication and cell homeostasis 
Chair: Christophe Erneux (Belgium)
    
■ 16.15-16.55 (40 min): V. Bankaitis (USA): Neural Stem Cell Phosphatidylinositol-4-Phosphate Signaling and Development of  the Mammalian Brain    
■ 16.55-17.35 (40 min): H. Stenmark (Norway): Class III PI 3-kinase and its catalytic product in regulation of cellular membrane dynamics                  
■ 17.35-18.15 (40 min): T. Balla (USA): Mapping the phosphatidylinositol landscape of eukaryotic cells    
■ 18.15-18.35 (20 min): M. Ebner (USA): PI4P metabolism by Sac1 and OSBP maintains a population of motile lysosomes  required for mTORC1 activation    
■ 18.35-18.55 (20 min): B. Emerling (USA): Targeting non-canonical phosphoinositide signaling for metabolic homeostasis 

■ 19.00-20.30: DINNER

■ 20.30-21.20 (50 min): THE SECOND JACQUES E. DUMONT KEYNOTE LECTURE 
Chair: Stephane Schurmans (Belgium) 

L. Weisman (USA): Cross-talk between phosphoinositide lipids, membrane trafficking and disease       
  
Please mount posters "session1” in the poster area     

■ 21.30: Poster session 1, wine/beer

THURSDAY 17th October 2019   

Session 1 (continued):     Phosphoinositides in intracellular trafficking, organelle communication and cell homeostasis Chair: Pierre De Meyts (Belgium)    

■ 09.00-09.40 (40 min): R. Botelho (Canada): The LYCAT phosphoinositide acyltransferase plays a critical role in the regulation of actin dynamics, cell migration and proliferation    
■ 9.40-10.20 (40 min): J. Brill (USA):  Roles and regulation of phosphatidylinositol 4-phosphate in vivo: lessons from Drosophila    
■ 10.20-10.40 (20 min): R. Padinjat (India): Extended synaptotagmin regulates plasma membrane-endoplasmic reticulum contact site structure and lipid transfer function in vivo   

 ■ 10.40-11.10: COFFEE BREAK     

Session 2:     Ca2+ signaling and Phosphoinositides/inositides signaling in the nucleus 
Chair: Veit Flockerzi (Austria)    

■ 11.10-11.50 (40 min): G. Bultynck (Belgium): Calcium signaling modulation by anti-apoptotic Bcl-2 in health & disease    
■ 11.50-12.30 (40 min): P. Hozak (Czech Republic): Identification of nuclear lipid islets as modulators of DNA transcription    

■ 12.35-14.00:   LUNCH    

■ 14.00-17:00: Walk around Mt Ste Odile 

■ 17.00-17.40 (40 min): A. Saiardi (UK): Strictly Soluble: the cytosolic (PLC-independent) pathway to IP6 synthesis is regulated by metabolism    
■ 17.40-18.20 (40 min): J. York (USA): Roles for Inositol Phosphates in Protein Folding and Function    
■ 18.20-18.40 (20 min): S. Shears (USA): Signal transduction and nutrient balance: regulation by IP8 of the cellular transport of inorganic phosphate  
  
■ 18.40-20.00:   DINNER    

■ 20.30-21.20 (50 min): KEYNOTE LECTURE  
Chair: David Carling (UK)    

A. De Matteis (Italy): ER-Golgi contact sites     

Please mount posters “session 2” in the poster area    

■ 21.30: Posters session 2, wine/beer
    
■ 21.30: Scientific Committee meeting

FRIDAY 18th October 2019   

Session 3 : Phosphoinositide metabolising enzymes in health and diseases, therapeutic perspectives 
Chair: Maria Sibilia (Austria) 
   
■ 08.30-09.10 (40 min): L. Cocco (Italy): Nuclear Phospholipase C isoenzyme imbalance leads to a number of pathologies   
■ 09.10-09.50 (40 min): S.H. Lehtonen (Finland): Lipid phosphatase SHIP2 - a therapeutic target for type 2 diabetes and diabetic kidney disease    
■ 09.50-10.10 (20 min): E. Owusu Obeng (Belgium): Biochemical properties of CRISPR SHIP2 MCF-7 cells   

■ 10.10-10.40:   COFFEE BREAK    

■ 10.40-11.20 (40 min): G. Canaud (France): Targeted therapy in patients with PIK3CA related overgrowth syndromes    
■ 11.20-12.00 (40 min): A. Bolino (Italy): Phosphoinositide metabolism and the control of Schwann cell myelination    
■ 12.00-12.20 (20 min): P. A. Koch (Germany): Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signaling via mTORC1    

■ 12.20-14.00:   LUNCH 

Session 4: Focus on class I, II and III PI 3-kinases 
Chair: Bernard Payrastre (France)

■ 14.30-15.10 (40 min): J.E. Burke (Canada): Novel mechanisms in the regulation of phosphoinositide kinases     
■ 15.10-15.30 (20 min): A. Ravussin (Norway): SNX4 is important for protein recycling during autophagy    
■ 15.30-15.50 (20 min): R. Blind (USA): IPMK kinase activity regulates class I HDAC function    
■ 15.50-16.10 (20 min): L. Gozzelino (Italy): Characterization of PI3KC2β in the pathogenesis of Focal Epilepsy   

■ 16.10-16.40:   COFFEE BREAK    

■ 16.40-17.20 (40 min): E. Hirsch (Italy): Class II PI3Ks in mitosis and cancer    
■ 17.20-17.40 (20 min): J. Laporte (France): Modulation of membrane remodeling or PI3K-C2β rescue myotubular myopathy due to mutations in myotubularin phosphoinositide phosphatase (MTM1)   
■ 17.40-18.00 (20 min): T. Anquetil (France):  PI3KC2β deficiency stabilizes VE-cadherin junction and preserves vascular integrity in stroke models   

■ 18.00-18.50 (50 min): KEYNOTE LECTURE 
Chair: Adriana Maggi (Italy)   

V. Haucke (Germany): Phosphoinositide conversion in endocytosis and nutrient signaling    

■ 19.00-21.00    SOCIAL EVENT AND GALA DINNER

Please mount posters “session 3” in the poster area    

■ 21.30: Posters sesion 3, wine/beer

SATURDAY 19th October 2014 
  
Session 4 (continued): Focus on class I, II and III PI 3-kinases 
Chair: Ilpo Huhtaniemi (UK)
    
■ 09.00-09.40 (40 min): Bart Vanhaesebroeck (UK): PI3K inhibitors in the clinic: are we getting there?    
■ 09.40-10.00 (20 min): B. Larijani (UK): Phosphoinositide- dependent oncoprotein activation and dynamics in Cancer - A quantitative imaging approach    
■ 10.00-10.20 (20 min): J. Guillermet-Guibert (France): The β isoform of PI3K positively controls Kras oncogenicity through autophagy-dependent dedifferentiation and rewiring of tissue repair mechanisms   

■ 10.20-10.45:   COFFEE BREAK    

■ 10.45-11.05 (20 min): B. Moes (Belgium): Role of the lipid 5-phosphatase Inpp5K in lymphocytes homeostasis and IL7-receptor signaling  
  
■ 11.05-11.55 (50 min): KEYNOTE LECTURE 
Chair : Jacques E. Dumont (Belgium)    

L. Stephens/P. Hawkins (UK): How is the acyl composition of phosphoinositides created and does it matter?    

■ 12.10-13.10:   BUFFET LUNCH     

■ 13.15:  BUS TRANSFER (from MSO to Strasbourg train station via airport)