47th Symposium on Hormones and Cell Regulation
NEW GPCR TARGETS FOR DISEASES
Jean-Philippe Pin & Ralf Jockers
Jean-Philippe Pin & Ralf Jockers
New GPCR targets for diseases
POC Chairs:
Jean-Philippe Pin Institut de Génomique Fonctionnelle, Univ. Montpellier, CNRS, INSERM
Ralf Jockers Functional Pharmacology and Pathophysiology of Membrane Receptors , Institut Cochin Paris, CNRS, INSERM
For any contact with the organization of the Congress ( J.E. Dumont Meeting Association)
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Wednesday PM
16:00 – 16:15 Welcome
Session 1: Molecular and cellular dynamics of GPCRs(Chair: TBC)
16:15 – 16:50 Emmanuel MARGEAT, FR
“Structural dynamics of
mGlu receptors by 2 and 3 colors smFRET”.
16:50
– 17:25 Davide CALEBIRO, UK
“New
insights into GPCR signalling from single-molecule microscopy”.
17:25 – 18:00 Tobias
LANGENHAN, DE
“Mechanosensing by adhesion G
protein-coupled receptors”.
18:00 – 18:30 2 x Research talks selected from
abstracts
18:30 – 20:00 Dinner
20:00 – 21:00 The
Jacques E. Dumont keynote lecture (Chair:
TBD)
Gebhard
SCHERTLER, CH
“From structural studies of GPCRs to
application: Engineering OptoGPCRs as scientific tools and for optogenetic applications”
21:00 Networking and discussion
Thursday AM
Thursday PM
Friday AM
Session 3: GPCRs as targets
for Metabolic Diseases (Chair: TBC)
09:00
– 9:35 Timo D MULLER, DE
“Novel
Insights into Regulation of Energy Metabolism by GIPR agonism and antagonism”.
09:35 – 10:10 Julie DAM, FR“A
non-canonical mechanism driving adipose tissue browning through a GPCR”
10:10 – 10:40 Coffee break
10:40 – 11:15 Shirly
PINTO, USA
“Activation
of gut enteroendocrine cells leads to synergistic hormone secretion in murine models and human, potentially playing a role
in weight loss and glucose control”
11:15 – 11:50 Zachary Gerhart-Hines, DK
“Long-acting
NK agonists”.
11:50 – 12:20 2 x Research
talks selected from abstracts
12:30 – 14:00 Lunch
Friday PM
Session 4: GPCRs as targets
for brain diseases (Chair: TBD)
14:00 – 14:35 Philippe RONDARD, FR
“Nanobodies targeting GPCRs
to treat brain diseases”.
14:35 – 15:10 Peter Jeffrey CONN, USA
“Muscarinic receptors as
targets for Schizophrenia”.
15:10 – 15:40 Coffee break
15:40 – 16:15 Kirill MARTEMYANOV, USA
“Glycine receptor: a new target for
antidepressants”.
16:15 – 16:50 Hélène CASTEL, FR " Urotensin II/UT G Protein-Coupled Receptor to
treat Glioblastoma"
16:50 – 17:25 TBD,
“TBA”.
17:25 – 18:10 3 x Research talks selected from abstracts
18:30 – 20:00 Dinner
20:00
– 21:00 Keynote lecture 3:
(Chair: TBD)
Prof Berhard
BETTLER, CH “Genetic Implication of GABAB Receptors in Neurological and Psychiatric Disorders“
21:00 Poster Session 2
Saturday AM
09:00 – 12:30 Session 5: AI to help GPCR drug
discovery(Chair: TBC)
9:00 – 09:35 Aurélien RIZK, InterAx Biotech, Villigen, Switzerland
“Modeling and predicting
GPCR signaling”
09:35
– 10:10 Chris de GRAAF, Structure Therapeutics,
Switzerland
“Structure-in-the-Loop
AI-Augmented GPCR Drug Discovery”.
10:10 – 10:40 Coffee break
10:40 – 11:15 Caroline LOW, Isomorphics Labs - UK
“Application
of ligand-protein structure prediction to GPCRs”.
11:15 – 11:45 TBD
"TBC"
11:45 – 12:15 2 x Research talks selected from abstracts
12:15 – 12:30 Wrap-up
12:30 Lunch and Departure